Dr. Katharina Reglinski

I am interested in the mechanisms and dynamics of peroxisomes and protein import into peroxisomes. As peroxisomes are small organelles, I apply (live) STED microscopy to investigate spatial organization and dynamics of peroxisomal proteins. This can reveal new understandings on processes like translocation of proteins across the peroxisomal membrane.
Publication list
  • Xiong Y.,  Jentzsch A.V., Osterrieth J.W.M.,  Sezgin E.,  Sazanovich I.V.,  Reglinski K.,  Galiani S., Parker A.W., Eggeling  C. and  Anderson H.L. Spironaphthoxazine switchable dyes for biological imaging. Chem. Sci., 2018,9, 3029-3040 doi: 10.1039/C8SC00130H (2018)
  • Galiani S., Waithe D., Reglinski K., Cruz-Zaragoza L.D., Garcia E., Clausen M.P., Schliebs W., Erdmann R. and Eggeling C. Super resolution microscopy reveals compartmentalization of peroxisomal membrane proteins. J. Biol. Chem. M116.734038. doi:10.1074/jbc.M116.734083 (2016)
  •  Reglinski K., Keil M., Altendorf S., Waithe D., Eggeling C., Schliebs W., Erdmann W. Peroxisomal import reduces the proapoptotic activity of Deubiquitinating Enzyme USP2. PLOS One 10(10): e0140685. doi:10.1371/journal.pone.0140685 (2015)
  • Fodor K., Wolf J., Reglinski K., Passon D.M., Lou Y., Schliebs W., Erdmann R. and Wilmanns M. Ligand-induced compaction of the PEX5 receptor-binding cavity regulates peroxisome import efficiency. Traffic; doi:10.1111/tra.12238 (2014)

CV
2005-2010 Studies of Biology and Biotechnology (Diploma), Ruhr-University Bochum, Germany
2010-2014 PhD, Institute of Physiological Chemistry, Systemic Biochemistry, Ruhr-University Bochum, Germany
2015 – 2019, PostDoc, Christian Eggeling Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford,  UK.
Since April 2019 Postdoc, Eggeling lab, Institute of Applied Optics and Biophysics, Fredrich-Schiller University, Jena