Dr. Katharina Reglinski

I am interested in the mechanisms and dynamics of peroxisomes and protein import into peroxisomes. As peroxisomes are small organelles, I apply (live) STED microscopy to investigate spatial organization and dynamics of peroxisomal proteins. This can reveal new understandings on processes like translocation of proteins across the peroxisomal membrane.

https://orcid.org/0000-0001-8994-067X

Publication list

• Galiani S*, Reglisnki K* et al. Diffusion and Interaction Dynamics of the Cytosolic Peroxisomal Import Receptor PEX5. bioRxiv. 2021 doi: 10.1101/2021.05.25.445571
  
• Reglinski K, Steinfort-Effelsberg L, Sezgin E, Klose C, Platta HW, Girzalsky W, Eggeling C, Erdmann R. Fluidity and Lipid Composition of Membranes of Peroxisomes, Mitochondria and the ER From Oleic Acid-Induced Saccharomyces cerevisiae. Front Cell Dev Biol. 2020;8:574363.
  
• Büttner M, Lagerholm CB, Waithe D, Galiani S, Schliebs W, Erdmann R, Eggeling C, Reglinski K. Challenges of using Expansion Microscopy for super-resolved imaging of cellular organelles. Chembiochem. doi: 10.1002/cbic.202000571.
  
• Waithe D, Brown JM, Reglinski K, Diez-Sevilla I, Roberts D, Eggeling C. Object detection networks and augmented reality for cellular detection in fluorescence microscopy. J Cell Biol. 2020;219(10):e201903166.
  
• Schneider KRA, Chettri A, Cole H, et al. Intracellular Photophysics of an Osmium Complex bearing an Oligothiophene Extended Ligand. Chemistry. 2020;10.1002/chem.202002667.
• Blayney J*, Foster EM*, Jagielowicz M*, Kreuzer M*, Morotti M*, Reglinski K*, Xiao JH*, Hublitz P. Unexpectedly High Levels of Inverted Re-Insertions Using Paired sgRNAs for Genomic Deletions. Methods Protoc. 2020, 3, 53. doi: 10.3390/mps3030053
• Xiong Y, Vargas Jentzsch A, Osterrieth JWM, et al. Spironaphthoxazine switchable dyes for biological imaging. Chem Sci. 2018;9(11):3029-3040. doi:10.1039/c8sc00130h
• Galiani S, Waithe D, Reglinski K, et al. Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins. J Biol Chem. 2016;291(33):16948-16962. doi:10.1074/jbc.M116.734038
• Reglinski K, Keil M, Altendorf S, et al. Peroxisomal Import Reduces the Proapoptotic Activity of Deubiquitinating Enzyme USP2. PLoS One. 2015;10(10):e0140685. doi:10.1371/journal.pone.0140685
• Fodor K, Wolf J, Reglinski K, et al. Ligand-induced compaction of the PEX5 receptor-binding cavity impacts protein import efficiency into peroxisomes. Traffic. 2015;16(1):85-98. doi:10.1111/tra.12238

*Equal contribution

CV

• 2005-2010 Studies of Biology and Biotechnology (Diploma), Ruhr-University Bochum, Germany
• 2010-2014 PhD, Institute of Physiological Chemistry, Systemic Biochemistry, Ruhr-University Bochum, Germany
• 2015 – 2019, PostDoc, Christian Eggeling Laboratory, Weatherall Institute of Molecular Medicine, University of Oxford, UK.
• Since April 2019 Postdoc, Eggeling lab, Institute of Applied Optics and Biophysics, Fredrich-Schiller University, Jena